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medRxiv PreprintsInternational13 November 2026

VectBox Sync: a web application for vectorcardiographic analysis of ventricular synchrony from 12-lead electrocardiograms

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We introduce VectBox Sync, a browser-based application that implements a published vectorcardiographic (VCG) dyssynchrony index for exploratory assessment of ventricular electrical synchrony from the 12-lead electrocardiogram (ECG). Despite guideline-directed patient selection, a substantial fraction of patients who receive cardiac resynchronization therapy (CRT) do not obtain the expected benefit. QRS duration and morphology remain the principal electrical criteria, yet they do not capture the three-dimensional trajectory of ventricular activation. VectBox Sync prioritizes native digital ECG
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