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medRxiv PreprintsInternational13 November 2026

Bivariate Multiscale Sample Entropy of Frontoparietal-Subgenual ACC Dynamics in Depression During Accelerated TMS at 7 T

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Objective: To examine whether longitudinal changes in frontoparietal (FP) - subgenual anterior cingulate cortex (sgACC) joint temporal complexity differ between sgACC hemispheres in patients undergoing accelerated TMS (aTMS) and untreated healthy controls. Methods: Twenty-four patients with current depressive episodes and fifteen healthy controls underwent 7T resting-state fMRI at baseline and follow-up. Patients received aTMS localized to the left DLPFC using Beam-F3. The same bilateral FP time series was paired separately with left and right sgACC time series. Bivariate multiscale sample ent
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