Unraveling the Lifespan Trajectory of White Matter Hypointensity on T1-weighted MR Images and Clinical Application in Various Brain Disorders

White matter hypointensity on T1-weighted MRI (T1-WMHypo), a putative marker of white matter pathophysiological changes, has been less systematically investigated than the widely studied T2-weighted fluid-attenuated inversion recovery (T2-FLAIR) hyperintensity lesions. Here, we built the lifespan normative reference and assessed the clinical significance of T1-WMHypo across various brain disorders using a large multicenter dataset. We first established lifespan normative reference for T1-WMHypo volume by 34,148 healthy individuals (aged 4-85 years). Then, in 7,587 patients across 21 neurologic

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