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medRxiv PreprintsInternational13 November 2026

Reliability-Aware Clinical Relation Learning for Uncertainty-Robust Multi-Label Chest X-ray Classification

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Background: Automated multi-label classification of chest radiographs is complicated by overlapping imaging findings, noisy report-derived labels, and changes in disease co-occurrence across clinical settings. Existing clinical-hierarchy methods can encode label relationships, but a rigid hierarchy may conflate categorical membership with empirical association and propagate annotation errors. Methods: We investigated Reliability-Aware Clinical Relation Learning (ReCaRL), a graph-assisted framework for multi-label chest radiograph classification. An image encoder produces initial finding scores
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