medRxiv PreprintsInternational13 November 2026
Protocol and Statistical Analysis Plan for the Hyperangulated versus Standard Geometry Laryngoscope Blade (ANGLE) Trial
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Background: Emergency tracheal intubation is common and high risk. Although guidelines recommend using a video laryngoscope to intubate critically ill adults, whether a hyperangulated or standard-geometry blade is more likely to achieve successful intubation on the first attempt remains unknown. Research Question: Does the use of a video laryngoscope with a hyperangulated blade increase the incidence of successful intubation on the first attempt among adults undergoing emergency tracheal intubation, compared to use of a video laryngoscope with a standard-geometry blade? Study Design and Method
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