Ontology-Based SEA-CDM Integration for Vaccine Clinical Trials: Query, Similarity, and Design Recommendation

ClinicalTrials.gov provides valuable information for vaccine research, but fragmented data structures and inconsistent vaccine naming complicate systematic cross-trial analysis. The Study-ExperimentAssay Common Data Model (SEA-CDM) provides a standardized structure for biomedical study data, while biomedical ontologies supply semantic relationships among concepts. We extracted 9,147 vaccinerelated study records from the Aggregate Analysis of ClinicalTrials.gov (AACT) database, mapped their records into SEA-CDM, and linked vaccine products and reported adverse events (AEs) to the Vaccine Ontolo

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