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medRxiv PreprintsInternational13 November 2026

Monocyte-to-lymphocyte and Platelet-to-lymphocyte ratios in Neuromyelitis Optica Spectrum Disorders: systematic review and meta-analysis

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Background: Neuromyelitis Optica Spectrum Disorders (NMOSD) are a group of neuroinflammatory conditions that affect the nervous system. MLR and PLR are simple inflammatory biomarkers and are studied in many autoimmune and demyelinating diseases. In this study, we investigate the available evidence to determine whether MLR and PLR are higher in NMOSD patients than in healthy subjects. Methods: Systematic review and meta-analysis of studies measuring levels of PLR and/or MLR in both NMOSD patients and healthy controls were conducted. Mean difference (MD) and 95% confidence interval (CI) were use
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