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medRxiv PreprintsInternational13 November 2026

Enrollees and Early Lessons from an Agentic Healthcare Platform with Physicians in the Loop

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Agentic healthcare platforms that combine large language models with physician oversight are growing quickly, but little is known about who uses them. We characterized 3,223 enrollees of Lotus AI, a free, physician-supervised agentic platform, who completed onboarding, messaged the agent, and had a linked health record between February and July 2026, and compared them with national benchmarks. Median age was 51 years and 62% were male. Chronic condition prevalence exceeded 2024 National Health Interview Survey estimates in every age band by 4 to 7 percentage points; 18% had a functional or sym
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