Clinical outcomes of bio-interventional cyclodialysis with one or multiple allogeneic reinforcements: a multicenter real-world evidence study

Introduction: Bio-reinforced cyclodialysis uses an acellular scleral allograft spacer to maintain a surgically created cleft and enhance uveoscleral outflow. Surgeons may place one spacer or two, but whether the second adds IOP lowering has not been reported. We tested whether two spacers achieve greater 12-month IOP reduction than one, and whether any difference persists after adjustment for measured baseline differences. Methods: Observational analysis of 310 eyes in the prospective, multicenter CREST study undergoing combined phacoemulsification and bio-reinforced cyclodialysis with one spa

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