The LAMp-LC Study: Unveiling the lung microbiome in Australians with early- and late-stage lung cancer using shotgun metagenomics

Lung cancer remains the leading cause of cancer-related mortality, yet the role of lower airway microbiota in disease development and progression is incompletely defined. Here, we characterised the lung microbiome in an Australian cohort (lung cancer n=106, healthy n=10) using shotgun metagenomics and semi-quantitative culture to evaluate site-specific microbial ecology across the tumour microenvironment (TME), contralateral airways, and oral cavity, to evaluate microbiome differences across early- and late-stage disease, and to quantify clinical covariate impacts on airway microbiota. Diversi

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