medRxiv PreprintsInternational12 November 2026
Influenza Vaccination and Disease Severity Among Older Adults Hospitalized with Influenza in France: A Nationwide Cohort Study, 2016-2024
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Objective Seasonal influenza remains a major cause of severe morbidity and mortality among older adults, despite vaccine availability. We assessed whether influenza vaccination was associated with reduced disease severity among adults aged 65 years or more hospitalized with influenza in France. Methods and Analysis We conducted a nationwide retrospective cohort study using the French National Health Data System (SNDS). Adults aged 65 years or more hospitalized with confirmed influenza (ICD-10 codes: J09 or J10) between October 2016 and December 2024 were included, excluding 2020-2021. Vaccinat
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