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medRxiv PreprintsInternational8 November 2026

The impact of climate variability on dengue virus case incidence in Sindh, Pakistan: Post-2022 flooding.

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Dengue virus is spread primarily by the Aedes aegypti and Ae. albopictus mosquitoes is a self-limiting viral disease primarily present in the tropical and subtropical regions of the world. Temperature and rainfall impact vector development, virus replication, and habitat suitability for Ae. aegypti and Ae. albopictus larvae and pupae. Pakistan, located in Southeast Asia, is one country where DENV is endemic and impacts thousands of lives each year. In recent years, Pakistan has been hardly hit by climate change, with heavy rainfalls and flooding recurring each year, with simultaneous surges of
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