medRxiv PreprintsInternational10 November 2026
The Antipsychotic Load (AP_Load2026): a normalised prescribed-dose index for schizophrenia research
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Background and Hypothesis Schizophrenia research routinely reduces antipsychotic treatment to a single number, but the available summaries disagree. Chlorpromazine equivalents, the WHO Defined Daily Dose (DDD) and the percentage of the licensed maximum (%BNFmax) rank the same patient differently, most of all for clozapine, whose dose-concentration relationship varies several-fold with sex and smoking. We hypothesised that referencing clozapine dose to a target individualised for sex and smoking would track plasma clozapine better than dose-proportional measures. Study Design In the Antipsychot
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