Tau-vulnerable medial temporal lobe connectivity drives a functional-to-synaptic cascade in Alzheimer's disease

Distinct tau-vulnerable and relatively spared subregions exist within the medial temporal lobe (MTL). However, it remains unclear that how functional connectivity (FC), anchored to tau-vulnerable MTL subregions, is related to tau pathology, synaptic dysfunction, and cognitive decline across the Alzheimer's disease (AD) continuum. We here probe into this with resting-state fMRI data from a discovery cohort (ADNI; N = 386; cognitively normal [CN], mild cognitive impairment [MCI], and AD; 144 with 2-year follow-up) and an independent validation cohort at local hospital (N = 100; CN, subjective co

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