Spatiotemporal mapping of ex vivo myometrial contractions in adenomyosis

Objective: Uterine dyscontractility plays a major role in pain sensation, infertility, and adenomyosis pathogenesis. In vivo, contractility occurs in the inner myometrium and junctional zone, which is thickened in adenomyosis. We examined whether the junctional zone presents particular contractile features ex vivo by measuring contractility and oxytocin response in full-thickness serosa-to-endometrium myometrial slices retrieved from control and adenomyosis patients. Design: Prospective ex vivo case-control study. Subjects: Premenopausal women following hysterectomy: adenomyosis (n = 16) and c

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