Single-cell profiling of human plaques reveals cellular and molecular signatures of symptomatic atherosclerosis

Atherosclerotic plaque vulnerability drives ischemic cardiovascular events, yet the cellular and molecular signatures distinguishing symptomatic from asymptomatic human plaques remain poorly defined. Here, we compared 53 symptomatic and asymptomatic human carotid plaques using single-nucleus (snRNA-seq; 17 samples, 19,100 nuclei; AtherOMICS biobank) and single-cell RNA sequencing (scRNA-seq; 36 samples, 68,983 cells; four public datasets), analyzed independently and combined by meta-analysis. Across sequencing approaches, symptomatic plaques showed cell-state shifts toward later or terminal st

This content is for informational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Consult a healthcare professional before starting any supplement, treatment, or program: especially if you are pregnant, nursing, taking medication, or managing a health condition.