medRxiv PreprintsInternational9 November 2026
SHARED GENETIC ARCHITECTURE AND DIRECTIONAL ASSOCIATIONS BETWEEN ATTENTION-DEFICIT/HYPERACTIVITY AND BORDERLINE PERSONALITY DISORDERS: AN INTEGRATIVE GENOMIC ANALYSIS
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Background: Attention-deficit/hyperactivity disorder (ADHD) and borderline personality disorder (BPD) frequently co-occur, but the contributions of shared genetic susceptibility and directional associations remain unclear. Methods: We analyzed European-ancestry GWAS summary statistics for ADHD (38,691 cases; 186,843 controls) and BPD (12,339 cases; 1,041,717 controls). Linkage disequilibrium score regression, conjunctional false discovery rate (conjFDR), bidirectional Mendelian randomization (MR), MR-LAP, CAUSE, colocalization, and SuSiE fine-mapping assessed genetic overlap and directional as
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