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medRxiv PreprintsInternational10 November 2026

Serum brain-derived tau distinguishes acute neurotrauma diagnoses

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Traumatic brain injury (TBI) and spinal cord injury (SCI) are two common forms of neurotrauma that can present with overlapping clinical features, complicating early diagnosis and management particularly in acute and mixed-trauma settings.1 - 3 Accurate and rapid biological differentiation remains an unmet need.4 We hypothesized that brain-derived tau (BD-tau), an ultrasensitive blood-based biomarker preferentially selective for tau protein originating from the brain, would distinguish TBI from SCI. In a multi-cohort assessment of 342 patients admitted to the neuro-intensive care unit (285 wit
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