Sentinel Event Surveillance to Identify Threats to SMC Effectiveness: Association Between Breakthrough Infections, SMC Uptake, Adherence and Parasite Drug Resistance

Seasonal malaria chemoprevention (SMC) is an important malaria prevention strategy used widely in areas of West Africa with highly seasonal transmission. Monthly administration of sulfadoxine-pyrimethamine plus amodiaquine (SPAQ) to young children during the high-transmission season substantially reduces malaria morbidity and mortality. SMC has recently been introduced in northern Kenya, where pastoralist communities experience intense malaria transmission. However, implementation in this setting presents unique challenges, including population mobility, vast distances, dispersed settlements,

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