Seek and You Will Find: A Prospective Case-Finding Study for the Detection of Neisseria gonorrhoeae Xpert(R) CT/NG Diagnostic Escape Mutants in England

Objectives: In 2025, the UK Health Security Agency (UKHSA), confirmed the identification of a Neisseria gonorrhoeae (NG) diagnostic escape mutant for the Xpert(R) CT/NG assay (Cepheid). Subsequently, a small number of further mutants were reported internationally. The assay comprises two NG-specific targets, NG2 and NG4, and amplification is required in both to report a positive result. This prospective case-finding study aimed to investigate the presence of diagnostic escape mutants in NG-negative specimens from two sexual health services using the Xpert(R) CT/NG assay to provide in-clinic te

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