medRxiv PreprintsInternational10 November 2026
Saccharomyces boulardii as Adjunctive Therapy in Helicobacter pylori Eradication: A Randomized, Placebo-Controlled Trial.
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Abstract Background: Helicobacter pylori (H. pylori) infection remains highly prevalent in Iran, where high antibiotic resistance can limit eradication efficacy. Saccharomyces boulardii (S. boulardii) may improve eradication and treatment tolerability, although evidence remains inconsistent. This trial evaluated adjunctive S. boulardii in a high-prevalence, high-resistance setting. Methods: In this randomized, single-blind, placebo-controlled trial, 218 H. pylori-positive adults received 14 days of PPI, bismuth, amoxicillin, and clarithromycin (P-BAC) plus either S. boulardii (250 mg twice dai
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