Quantifying age-associated differences in the durability of Shingrix-induced immunity using mathematical modelling

Understanding the durability of vaccine-induced immunity is critical for evaluating long-term protection and vaccine scheduling, particularly in aging populations where immunosenescence may alter immune response dynamics. In this study, we used a novel mathematical modelling pipeline to quantify age-related differences in the contraction and persistence phases of gE-specific CD4+ T cell and anti-gE antibody responses following Shingrix vaccination. Specifically, we developed a semi-mechanistic model to expand virtual populations that captured inter-individual variability in peak concentrations

This content is for informational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Consult a healthcare professional before starting any supplement, treatment, or program: especially if you are pregnant, nursing, taking medication, or managing a health condition.