Proteomic profiling of postmortem prefrontal cortex identifies molecular signatures of borderline personality disorder

Borderline personality disorder (BPD) is characterized by a severe pattern of symptoms including emotional instability, impulsivity, and unstable interpersonal relationships. A complex interplay between genetics and environmental factors has been hypothesized to be associated with the development of BPD. While neuroimaging studies have identified structural and functional changes in the brain, and genome-wide association studies described some first genetic risk loci, the neurobiological underpinnings of BPD remain poorly described. To better understand disease processes in BPD, we performed a

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