PNEUMOCOCCAL CONJUGATE VACCINE SCHEDULES SHAPE SEROTYPE-SPECIFIC MEMORY B-CELL RESPONSES

Reduced-dose pneumococcal conjugate vaccine (PCV) schedules (1+1; one primary and one booster) are now endorsed by the World Health Organisation under specific circumstances. Serotype-specific memory B cells (BMEM) are a marker of long-term protection but data from infant reduced-dose trials remain limited. As part of a randomised controlled trial in Vietnamese infants, we characterised serotype-specific BMEM responses in randomised subsets (N=50 per vaccine group per timepoint) following 0+1 (at 12 months of age) or 1+1 (2 and 12 months of age) schedules of PCV10 or PCV13, using a multimer sp

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