medRxiv PreprintsInternational9 November 2026
Plasma phosphorylated tau species across neurodegenerative and cerebrovascular diseases: An ONDRI study
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Elevated plasma phosphorylated tau (p-tau) species are proposed as specific biomarkers of Alzheimer's disease (AD) pathology but have also been reported in amyotrophic lateral sclerosis (ALS). Their profile across neurodegenerative and cerebrovascular diseases, as well as their discriminatory value when combined with other plasma biomarkers, remain uncertain. We studied 551 participants (ages 40.1 to 87.1 years; 207 women), comprising 506 patients from the Ontario Neurodegenerative Disease Research Initiative (ONDRI) multi-site cohort and 45 amyloid-{beta} (A{beta}) PET-negative cognitively un
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