Persistent or recurrent depression in young adults: associations with systemic inflammation and early life adversity.

Background There is limited research on persistent or recurrent depression into young adulthood. We examined the prevalence of recurrent/persistent depression in young adults, and associations with childhood trauma/adversity and systemic inflammation, and if inflammatory markers mediated associations between childhood trauma and subsequent depression. Methods ALSPAC participants with ICD-10 depression assessments at ages 18, 24 and 30 were classified as never depressed, transiently depressed (one episode), or persistently/recurrently depressed ([≥] 2). Trauma/adversity from birth to age 16/

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