medRxiv PreprintsInternational10 November 2026
Peripheral Blood NADP(H) Redox Metabolism in Alzheimers Disease and Mild Cognitive Impairment: A Systematic Review and Meta-analysis Where Feasible
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Background: The reduced and oxidized forms of nicotinamide adenine dinucleotide phosphate (NADPH/NADP) connect cellular reducing power with the glutathione and thioredoxin systems. Peripheral alterations in this network may reflect systemic redox dysregulation in Alzheimer s disease (AD) and mild cognitive impairment (MCI), but the evidence has not been quantitatively synthesized. Objective: To systematically evaluate peripheral blood NADP(H) redox metabolism and related enzymes in AD and MCI and to perform meta analyses when the available data were sufficiently comparable.
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