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medRxiv PreprintsInternational10 November 2026

Pediatric lumbar puncture rates in urban tertiary hospitals in Africa participating in the SURE pediatric tuberculous meningitis treatment trial

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Abstract: Lumbar puncture (LP) and cerebrospinal fluid (CSF) analysis are essential for the diagnosis and management of central nervous system (CNS) infections, but LP is underutilised in pediatric patients in high burden settings. As part of the pre-screening and screening procedures of the SURE+DP diagnostic sub-study of the SURE pediatric tuberculous meningitis randomised control trial we identified this as a key clinical issue and quantified how often pediatric lumbar puncture was performed at recruiting African hospitals and implemented a package of interventions to increase LP rates. Met
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