Optimizing dosing strategies for children with leprosy: A weight-banded dosing approach

Background: Dosing guidance for children with leprosy remains operationally challenging. For children under 10 years of age, current WHO recommendations rely on mg/kg dosing of the three separate components of leprosy multidrug therapy, which are difficult to implement in routine care and may result in inconsistent drug exposures. Weight-banded dosing offers a pragmatic alternative that better aligns with pharmacokinetic principles and existing drug formulations. Methodology: A pharmacokinetic simulation study was conducted to develop harmonized weight-banded dosing regimens for rifampicin, cl

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