Myeloid subpopulations correlate with responsiveness to therapy in a prospective, longitudinal study on RA patients

Background: Rheumatoid arthritis (RA) is an autoimmune disease associated with the destruction of cartilage and bone, increased risk of cardiovascular disease and a higher mortality rate. Despite the many therapies that exist for RA, there is little information to guide selection of the most effective treatment for an individual patient. Ultrasound-guided synovial biopsies have created an opportunity to investigate the target tissue. While a number of studies have characterized the stromal and immune cell populations using single-cell technology on synovial biopsy samples, here we performed a

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