medRxiv PreprintsInternational11 November 2026
Mucin VNTR haplogroup associations with idiopathic pulmonary fibrosis are not independent of rs35705950
This is an official announcement record
Firsthand records what medRxiv Preprints announced and links to the original. The wording below is theirs, not ours.
Background: The MUC5B promoter variant (rs35705950) is the strongest common genetic risk factor for idiopathic pulmonary fibrosis (IPF). MUC5B and MUC5AC contain variable number tandem repeat (VNTR) regions. Long-read sequencing resolves MUC5AC into three SNP-tagged haplogroups (H1, H2, H3) differing in repeat length, and MUC5B into two (H1, H2) differing in lineage but not length. The tags correlate with rs35705950, so whether a haplogroup effect is distinguishable from the promoter variant is unclear. Methods: We assigned MUC5AC and MUC5B haplogroups from imputed chromosome 11 array data in
Read the official announcement
Opens www.medrxiv.org
More from medRxiv Preprints
- Silent Drift and Site-level Variance in Clinical AI: Real-world performance and subgroup analysis for post-market monitoring of an FDA-cleared artificial intelligence (AI) triage tool for high-risk use case of pulmonary embolism12 November 2026
- Determinants of mpox vaccine acceptance among peri-urban residents in Sekondi-Takoradi, Western Region of Ghana: A community-based cross-sectional study12 November 2026
- Mapping disordered eating symptoms in the ABCD Study through the Eating Disorder Symptom Index12 November 2026
- Influenza Vaccination and Disease Severity Among Older Adults Hospitalized with Influenza in France: A Nationwide Cohort Study, 2016-202412 November 2026
- Associations of drinking water per- and polyfluoroalkyl substances with cause-specific mortality in men with prostate cancer12 November 2026
This content is for informational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Consult a healthcare professional before starting any supplement, treatment, or program: especially if you are pregnant, nursing, taking medication, or managing a health condition.