medRxiv PreprintsInternational8 November 2026
Methodological Adherence, Reporting Completeness, and Risk of Bias in AI-Assisted Systematic Reviews: A Matched Meta-Research Study
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Background: Artificial intelligence (AI) is increasingly used to accelerate systematic reviews that inform clinical practice and policy. However, evidence on the methodological adherence, reporting completeness, and risk of bias of completed AI-assisted reviews is limited. Objective: To compare methodological adherence, reporting completeness, and risk of bias between published systematic reviews with reported AI assistance and matched reviews with no reported AI use, and to assess AI-use transparency. Methods: We conducted a matched-cohort meta-research study of English-language, peer-reviewe
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