Metabolome-wide Association Study of Bronchopulmonary Dysplasia in Extremely Premature Infants

Rationale: Untargeted metabolomics may identify novel pathways involved in bronchopulmonary dysplasia (BPD), a poorly understood lung disease in extremely premature infants. Objective: To identify metabolites and pathways altered in infants who develop BPD through a metabolome-wide association study. Methods: We performed untargeted urinary metabolomics in 314 infants (<29 weeks gestational age) at two time points between postnatal days 5-15 and 23-32, with detailed time-series for 28 infants. We compared metabolite levels between infants with and without BPD at 36 weeks postmenstrual age usin

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