medRxiv PreprintsInternational9 November 2026
Longitudinal Investigation of Autonomic Symptoms in Biologically Confirmed (SAA+) Parkinson's Disease
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Background Autonomic symptoms are common in Parkinson disease (PD) and impact quality of life, with unclear relationship to motor and cognitive progression. Objective: Characterize five-year progression of autonomic symptoms in early PD and their association with motor and cognitive outcomes. Methods We analyzed data from 874 PD participants and 252 healthy controls (HC) enrolled in Parkinson Progression Markers Initiative (PPMI). Autonomic symptoms were assessed annually over five years using Scales for Outcomes in Parkinson's disease-Autonomic dysfunction (SCOPA-AUT); affected autonomic doma
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