Longitudinal Cerebrospinal Fluid Biomarker Changes Following Shunt Surgery in Idiopathic Normal Pressure Hydrocephalus - Insights from the Gothenburg POiNT study

Background The underlying pathophysiology of idiopathic normal pressure hydrocephalus (iNPH) is incompletely understood and reliable predictors of shunt response are lacking. Cerebrospinal fluid (CSF) biomarkers may provide insights into disease mechanisms and help identify patients most likely to benefit from surgery. The aim of this study was to explore CSF biomarker dynamics following shunt surgery and their relationship with clinical outcome. Methods The POiNT (Prediction of Outcome in iNPH) was a prospective longitudinal study. One hundred and thirty-five patients with iNPH underwent stan

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