Lipidome-wide analysis of concurrent and longitudinal blood pressure patterns in school-aged children

Background: Elevated blood pressure (BP) in childhood is associated with cardiovascular risk, but its molecular lipid correlates remain poorly characterized. We investigated the association of plasma lipid species and patterns with concurrent and longitudinal BP phenotypes in school-aged children. Methods: In the Belgian ENVIRONAGE prospective birth-cohort, 195 children aged 9 to 12 years were examined between July 2021 and September 2024. A total of 1,232 plasma lipid species were quantified using liquid chromatography-electrospray ionization-tandem mass spectrometry. Associations with systol

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