medRxiv PreprintsInternational10 November 2026
Lamina Cribrosa Strain as a Glaucoma Prognostic Factor: The STRAIN Study Methodology and Initial Outcomes
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Objective: To estimate the lamina cribrosa (LC) strain response to intraocular pressure (IOP) change in open angle glaucoma (OAG) patients and examine associations between LC strain and demographic and clinical characteristics relevant to OAG in an ongoing longitudinal study. Design: Cohort study Participants: Adult patients with OAG (205 eyes of 119 patients) Methods: The STRAIN study is an ongoing longitudinal study designed to determine whether LC biomechanical strain is associated with present, prior, and future OAG damage. In this initial analysis, patients either temporarily stopped [&ge
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