Investigating Biological Aging Measures, Neurocognitive Performance, and Depressive Symptoms: Moderating Effects of HIV and Childhood Maltreatment

Introduction: Neurocognitive impairment and depression remain common among people with HIV (PWH), and childhood maltreatment (CM) may further increase vulnerability. In this cohort, we previously reported that PWH exhibited shorter absolute telomere length, lower MRI-based brain-predicted age difference, and greater epigenetic age acceleration (AA) compared to controls, with limited associations with CM severity. Building on this, the present study examines whether these markers are linked to neurocognitive performance and depressive symptoms, and whether HIV status or CM severity moderates su

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