Higher platelet counts are associated with migraine risk across three cohorts among more than 21,000 cases

Objective We assessed potential associations between migraine and complete blood cell count (CBC) data in three large population-based studies. Background Platelets are thought to be involved in migraine pathology through increased activation during an attack. Migraine attacks are often treated with NSAIDs that inhibit platelets, or triptans that target serotonin receptors, with serotonin being most highly expressed in circulation within platelet granules. However, the exact role of platelets in migraine remains unclear. Methods The UK BioBank (UKBB) has CBC data available from baseline blood

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