Handheld, quantitative phase imaging probe for skin evaluation at subcellular resolution in vivo, in real-time, and in 3D

Skin cancer is the most common malignancy in the United States. The gold standard for diagnosis of skin cancer is histopathological analysis via tissue biopsy. However, identifying which lesions to biopsy remains a significant clinical challenge, particularly at early stages of disease. In this work, we present a volumetric quantitative oblique back-illumination microscopy (qOBM) probe, a highly maneuverable, handheld imaging system capable of providing high-resolution, 3D visualization of the skin microstructure. We show the probe is capable of visualizing the dynamic, layered microstructure

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