Genomic Studies in Blood and Marrow Transplantation (GS-BMT): An NCI-CIBMTR genomic medicine initiative in hematopoietic cell transplantation

Background: Genomic studies in hematopoietic cell transplantation (HCT) are limited by sample sizes and targeted approaches. Methods: The Genomic Studies in Blood and Marrow Transplantation (GS-BMT) project is a collaboration between the National Cancer Institute (NCI) and the CIBMTR designed to investigate recipient and donor determinants of HCT outcomes. We are generating genome-wide SNP-array genotyping for all samples, and sequencing and methylation profiling for selected subsets. We report study design and cohort characteristics and present two proof-of-concept analyses: comparison of con

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