Genome-Wide Study of Early Disability Severity in Multiple Sclerosis

Background and Objectives: Multiple sclerosis (MS) is a chronic neurological disorder characterized by demyelination and neuroaxonal injury. MS genetic susceptibility and severity long after disease onset is well characterized, but the genetic architecture of disability severity near disease onset is unclear. We performed the first genome-wide association study of early MS severity to identify causal loci, prioritize effector genes and associated pathways, and understand the relationships of early MS severity and various traits. Methods: The primary outcome was the first age-related MS severit

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