Genome-wide association meta-analysis of atrophic gastritis reveals anti H. pylori IgG serostatus dependent associations and genetic overlap with gastric cancer

Background Atrophic gastritis (AG), characterized by chronic inflammation of the gastric mucosa and glandular atrophy, is an established precursor of gastric cancer (GC) and contributes to iron-deficiency anemia, vitamin B12 deficiency, and pernicious anemia. Although Helicobacter pylori infection is a major environmental determinant, not all infected individuals develop AG or GC, suggesting that host genetic factors influence susceptibility to AG and severe atrophic gastritis (SAG). Previous genome-wide association studies (GWAS) of AG have been limited in size and have not adequately compare

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