Genetic effects on serum and urine metabolites across ancestries and their links to disease

Genome-wide association studies of the metabolome have predominantly examined European-ancestry populations using a single biofluid, constraining both the discovery of metabolite quantitative trait loci (mQTLs) and the resolution of causal variant finemapping. Here, we report a multi-ancestry genome-wide association study of 1,955 serum and urine metabolites in 4,431 European American and African American participants from the Atherosclerosis Risk in Communities study. We identify 969 mQTLs for 553 metabolites, 30% unreported in studies of matched biofluid and ancestry, and replicate 91-99% of

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