Gamma delta T cells are expanded in the blood of chronic low back pain patients with lumbar Modic changes

Objectives Modic changes (MC) are vertebral endplate and bone marrow lesions strongly associated with chronic low back pain. Type 1 MC (MC1, oedema-like) and type 2 or 3 MC (MC2or3, fat- and sclerosis-like) are commonly regarded as different stages of the same pathological process, yet their underlying biology remains poorly defined. In particular, it remains unclear whether MC are confined to the spine or accompanied by distinct systemic immune alterations. Here, we provide the first comprehensive characterisation of the circulating immune landscape in patients with lumbar MC. Methods Periphe

This content is for informational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Consult a healthcare professional before starting any supplement, treatment, or program: especially if you are pregnant, nursing, taking medication, or managing a health condition.