medRxiv PreprintsInternational10 November 2026
Five Days of Acute Intermittent Hypoxia Is Safe and Improves Somatic Motor Function in Persons with Multiple Sclerosis
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BACKGROUND/OBJECTIVES Walking impairment affects up to 75% of persons with multiple sclerosis (MS), and the benefits of rehabilitation are constrained by limited capacity for training-induced neuroplasticity. Acute intermittent hypoxia (AIH), brief repeated exposures to low inspired oxygen, triggers serotonin-dependent spinal plasticity that enhances motor output. In spinal cord injury, daily AIH paired with walking training has produced larger walking gains than training alone, positioning AIH as a promising primer for rehabilitation. Before AIH can be combined with training in MS, its safety
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