medRxiv PreprintsInternational12 November 2026
Environmental Chemical Exposures and Accelerated Epigenetic Aging: Links to Metabolic and Age-Related Health Outcomes
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Environmental chemical exposures may influence biological aging, but their relationships with epigenetic aging and related health outcomes remain incompletely understood. In this study, we evaluated the associations of 13 environmental exposures, including heavy metals, polycyclic aromatic hydrocarbons (PAHs), and volatile organic compounds (VOCs), with epigenetic aging in 666 older adults from the Forensic Research via Omics Markers in Environmental Health Vulnerable Areas (FROM) cohort. Among the evaluated epigenetic aging biomarkers, GrimAge acceleration showed the most prominent associatio
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