Enrichment of Rare Exonic Variants in Cognitive Superagers from Centenarian Families

Although cognitive decline and dementia are common at advanced ages, a fraction of individuals reach extreme ages maintaining high levels of cognitive function. Here, we compared whole-exome sequencing data from 136 cognitive superagers, individuals whose memory performance matches normative expectations for persons ~30 years younger, to 114 average-cognition controls and the gnomAD population reference database. While standard single-variant and burden analyses did not identify exome-wide significant loci, a rare variant allele frequency analysis identified 114 significant rare coding variant

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