Electromechanical Drivers of Diastolic Dysfunction During Hypertrophic Cardiomyopathy Progression

Aims: Diastolic dysfunction in hypertrophic cardiomyopathy reflects changes in sarcomeric function, electrophysiology, ventricular structure, and myocardial mechanics. Their effects on filling remain difficult to determine clinically. We sought to dissect these effects in MYH7-related non-obstructive hypertrophic cardiomyopathy progression. Methods and results: We developed a human biventricular electromechanical model linking electrophysiology and calcium handling to contraction, ventricular mechanics, haemodynamics, electrocardiography, and myocardial strain. Stage I represented MYH7 sarcome

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