Cytokine Signatures of Immune Checkpoint Inhibitor Myocarditis and the Modifying Role of Clonal Hematopoiesis: A Machine-Learning and Multi-Omics Study

Background Immune checkpoint inhibitor (ICI) myocarditis affects up to 2% of patients on ICI and has up to a 50% mortality. Clonal Hematopoiesis of Indeterminate Potential (CHIP) is a risk factor for ICI myocarditis. Objectives: To leverage a multi-omics approach to evaluate cytokines associated with ICI myocarditis, immunosuppression resistance, CHIP in ICI myocarditis and implicated pathways and cell type contributions. Methods 236 cardio-oncology patients were enrolled, including 88 who were on ICI. Cytokine profiling from patients on ICI were sampled and analyzed using machine learning and

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